English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Discontinuities in slow finger movements in patients with Parkinson's disease

Bettray, L., Eggers C, Quatuor E-L, Florin, E., Reck C, Pauls AKM, Barbe MT, Fink, G., & Timmermann, L. (2013). Discontinuities in slow finger movements in patients with Parkinson's disease. Neuroscience Letters, 548, 10–14. doi:10.1016/j.neulet.2013.02.068.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Bettray, LM, Author
Eggers C, Quatuor E-L, Florin, E1, Author              
Reck C, Pauls AKM, Barbe MT, Fink, GR, Author
Timmermann, L, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Slow finger movements in healthy humans are characterized by discontinuous rhythmic changes in a low frequency band about 8 Hz. These pulsatile changes in velocity are thought to present the central output of an oscillatory cerebello-thalamo-cortical network in the same frequency. Hypothesizing that patients with Parkinson's disease (PD) in the dopaminergic OFF- and ON-condition show changes in the characteristics of discontinuities compared to healthy humans, we used a 3D-ultrasound device to measure slow finger movements of 16 patients with PD and 12 age-matched controls. We provide evidence that slow finger movements of patients with PD are characterized by discontinuities in acceleration, which are significantly slower in the OFF- but not in the ON-condition compared to healthy controls. Correlation analysis between clinical motor improvement after dopaminergic medication and changes of peak frequencies and peak power of discontinuities was not significant. We conclude that the oscillatory brain network of slow finger movements is affected in PD, presenting in a lower frequency in the OFF-condition. We suggest that one factor of the modulation of this network is a dopaminergic stimulation.

Details

show
hide
Language(s):
 Dates: 2013-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuroscience Letters
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 548 Sequence Number: - Start / End Page: 10–14 Identifier: -