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  Exenatide-Induced Reduction in Energy Intake Is Associated With Increase in Hypothalamic Connectivity

Schlögl, H., Kabisch, S., Horstmann, A., Lohmann, G., Müller, K., Lepsien, J., et al. (2013). Exenatide-Induced Reduction in Energy Intake Is Associated With Increase in Hypothalamic Connectivity. Diabetes Care, 36(7), 1933-1940. doi:10.2337/dc12-1925.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-14DF-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3EFA-1
Genre: Journal Article

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Schlögl, H, Author
Kabisch, S, Author
Horstmann, A, Author
Lohmann, Gabriele1, Author              
Müller, K, Author
Lepsien, J, Author
Busse-Voigt , F, Author
Kratzsch, J, Author
Pleger, B, Author
Villringer, A, Author
Stumvoll, M, Author
Affiliations:
1Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, ou_persistent22              

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 Abstract: OBJECTIVE Glucagon-like peptide-1 receptor agonists such as exenatide are known to influence neural activity in the hypothalamus of animals and to reduce energy intake. In humans, however, significant weight loss has been observed in only a subgroup of patients. Why only some individuals respond with weight loss and others do not remains unclear. In this functional magnetic resonance imaging (fMRI) study, we investigated differences in hypothalamic connectivity between “responders” (reduction in energy intake after exenatide infusion) and “nonresponders.” RESEARCH DESIGN AND METHODS We performed a randomized, double-blinded, placebo-controlled, cross-over fMRI study with intravenous administration of exenatide in obese male volunteers. During brain scanning with continuous exenatide or placebo administration, participants rated food and nonfood images. After each scanning session, energy intake was measured using an ad libitum buffet. Functional hypothalamic connectivity was assessed by eigenvector centrality mapping, a measure of connectedness throughout the brain. RESULTS Responders showed significantly higher connectedness of the hypothalamus, which was specific for the food pictures condition, in the exenatide condition compared with placebo. Nonresponders did not show any significant exenatide-induced changes in hypothalamic connectedness. CONCLUSIONS Our results demonstrate a central hypothalamic effect of peripherally administered exenatide that occurred only in the group that showed an exenatide-dependent anorexigenic effect. These findings indicate that the hypothalamic response seems to be the crucial factor for the effect of exenatide on energy intake.

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 Dates: 2013-07
 Publication Status: Published in print
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 Identifiers: DOI: 10.2337/dc12-1925
BibTex Citekey: SchloglKHLMLBKPVS2013
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Title: Diabetes Care
Source Genre: Journal
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Pages: - Volume / Issue: 36 (7) Sequence Number: - Start / End Page: 1933 - 1940 Identifier: -