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  Dopamine Replacement Modulates Oscillatory Coupling Between Premotor and Motor Cortical Areas in Parkinson's Disease

Herz, D., Florin, E., Christensen, M., Reck, C., Barbe, M., Tscheuschler, M., et al. (2014). Dopamine Replacement Modulates Oscillatory Coupling Between Premotor and Motor Cortical Areas in Parkinson's Disease. Cerebral Cortex, 24(11), 2873-2883. doi:10.1093/cercor/bht140.

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Herz, DM, Author
Florin, E1, Author              
Christensen, MS, Author
Reck, C, Author
Barbe, MT, Author
Tscheuschler, MK, Author
Tittgemeyer, M, Author
Siebner, HR, Author
Timmermann, L, Author
Affiliations:
1Department of Neurology, University Hospital Cologne, Cologne, Germany, ou_persistent22              

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 Abstract: Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.

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 Dates: 2013-062014-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1093/cercor/bht140
BibTex Citekey: HerzFCRBTTST2014
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Title: Cerebral Cortex
Source Genre: Journal
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Pages: - Volume / Issue: 24 (11) Sequence Number: - Start / End Page: 2873 - 2883 Identifier: -