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  Mapping of arterial transit time by intravascular signal selection

Mildner, T., Mueller, K., Hetzer, S., Trampel, R., Driesel, W., & Möller, H. E. (2014). Mapping of arterial transit time by intravascular signal selection. NMR in Biomedicine, 27(5), 594-609. doi:10.1002/nbm.3098.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-298E-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F4E-9
Genre: Journal Article

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 Creators:
Mildner, Toralf1, Author              
Mueller, Karsten1, Author              
Hetzer, Stefan2, Author              
Trampel, Robert3, Author              
Driesel, Wolfgang1, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Perfusion imaging; Perfusion modeling; Dual-coil CASL; Arterial transit time; Intravascular signal; Flow weighting; Vascular territories; Border zone regions
 Abstract: The arterial transit time (δa) is a potentially important physiological parameter which may provide valuable information for the characterization of cerebrovascular diseases. The present study shows that δa can be measured by arterial spin labeling (ASL) applied quasi-continuously in an amplitude-modulated fashion at the human neck. Imaging was performed using short repetition times and excitation flip angles of 90°, which resulted in the selection of an ASL signal of mostly intravascular origin. Model-independent estimates of δa were obtained directly from the temporal shift of the ASL time series. An extended two-compartment perfusion model was developed in order to simulate the basic features of the proposed method and to validate the evaluation procedure. Vascular structures found in human δa maps, such as the circle of Willis or cerebral border zones, hint at the sensitivity of the method to most sizes of arterial vessels. Group-averaged values of δa measured from the carotid bifurcation to the tissue of interest in selected regions of the human brain ranged from 925 ms in the insular cortex to 2000 ms in the thalamic region.

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Language(s): eng - English
 Dates: 2014-02-032013-03-212014-02-032014-03-092014-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/nbm.3098
PMID: 24610794
Other: Epub 2014
 Degree: -

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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 27 (5) Sequence Number: - Start / End Page: 594 - 609 Identifier: ISSN: 0952-3480
CoNE: /journals/resource/954925574973