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  Self-reflection and positive schizotypy in the adolescent brain

Debanne, M., Vrticka, P., Lazouret, M., Badoud, D., Sander, D., & Eliez, S. (2014). Self-reflection and positive schizotypy in the adolescent brain. Schizophrenia Research, 152(1), 65-72. doi:10.1016/j.schres.2013.06.027.

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 Creators:
Debanne, Martin1, 2, Author
Vrticka, Pascal3, 4, 5, Author              
Lazouret, Marine1, 2, Author
Badoud, Deborah1, 2, Author
Sander, David3, 4, Author
Eliez, Stephan2, 6, Author
Affiliations:
1Adolescence Clinical Psychology Unit, University of Geneva, Switzerland, ou_persistent22              
2Department of Psychiatry, University Hospital of Geneva, Switzerland, ou_persistent22              
3Swiss Center for Affective Sciences, University of Geneva, Switzerland, ou_persistent22              
4Laboratory for the Study of Emotion Elicitation and Expression, Department of Psychology, University of Geneva, Switzerland, ou_persistent22              
5Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, CA, USA, ou_persistent22              
6Department of Genetic Medicine and Development, University of Geneva, Switzerland, ou_persistent22              

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Free keywords: fMRI; Cortical midline; Psychosis; Hallucinations; Delusions; Connectivity
 Abstract: Clinical and phenomenological accounts of schizophrenia suggest that impairments in self-reflective processes significantly contribute to psychopathological expression. Recent imaging studies observe atypical cerebral activation patterns during self-reflection, especially around the cortical midline structures, both in psychosis-prone adults and individuals with schizophrenia. Given that self-reflection processes consolidate during adolescence, and that early transient expression of psychosis (positive schizotypy) also arises during this period, the present study sought to examine whether atypical cerebral activation during self-reflection task could be associated with early schizotypic expression during adolescence. Forty-two neurotypical adolescent participants (19 females) aged from 12 to 19 (15.92 ± 1.9) underwent a self-reflection task using functional neuroimaging (fMRI), where they had to evaluate trait adjectives (1 to 4 ratings) about themselves or their same sex best friend. The Schizotypal Personality Questionnaire (SPQ) was employed to assess positive schizotypic expression. Results showed that positive schizotypy in adolescents significantly correlated with cortical midline activation patterns in the dorsomedial prefrontal cortex (dmPFC) and the posterior cingulate cortex (PCC), as well as the dorsolateral PFC and the lingual gyrus. The results are consistent with previous imaging literature on self-reflection and schizophrenia. They further highlight that the relationship between self-reflection processes and positive schizotypy operates at the trait level of expression and can be observed as early as adolescence.

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Language(s): eng - English
 Dates: 2013-02-152013-06-102013-06-292014-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.schres.2013.06.027
PMID: 23819895
Other: Epub 2013
 Degree: -

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Title: Schizophrenia Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 152 (1) Sequence Number: - Start / End Page: 65 - 72 Identifier: ISSN: 0920-9964
CoNE: https://pure.mpg.de/cone/journals/resource/954925564675