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  The impact of stimulus valence and emotion regulation on sustained brain activation: Task-rest switching in emotion

Lamke, J.-P., Daniels, J. K., Dörfel, D., Gaebler, M., Rahman, R. A., Hummel, F., et al. (2014). The impact of stimulus valence and emotion regulation on sustained brain activation: Task-rest switching in emotion. PLoS One, 9(3): e93098. doi:10.1371/journal.pone.0093098.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-423E-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7CC5-4
Genre: Journal Article

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 Creators:
Lamke, Jan-Peter1, 2, Author
Daniels, Judith K.1, 3, Author
Dörfel, Denise1, Author
Gaebler, Michael1, 2, 4, Author              
Rahman, Rasha Abdel2, 5, Author
Hummel, Falk6, Author
Erk, Susanne1, Author
Walter, Henrik1, 5, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
3Department of Psychosomatic Medicine and Psychotherapy, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
6Department of Psychiatry and Psychotherapy, University Bonn, Germany, ou_persistent22              

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 Abstract: Task-rest interactions, defined as the modulation of brain activation during fixation periods depending on the preceding stimulation and experimental manipulation, have been described repeatedly for different cognitively demanding tasks in various regions across the brain. However, task-rest interactions in emotive paradigms have received considerably less attention. In this study, we therefore investigated task-rest interactions evoked by the induction and instructed regulation of negative emotion. Whole-brain, functional MRI data were acquired from 55 healthy participants. Two-level general linear model statistics were computed to test for differences between conditions, separately for stimulation and for fixation periods, as well as for interactions between stimulation and fixation (task-rest interactions). Results showed that the regulation of negative emotion led to reverse task-rest interactions (decreased activation during stimulation but increased activation during fixation) in the amygdala as well as in visual cortex regions and to concordant task-rest interactions (increased activation during both, stimulation and fixation) in the dorsolateral prefrontal cortex as well as in a number of brain regions at the intersection of the default mode and the dorsal attention networks. Thus, this first whole-brain investigation of task-rest interactions following the induction and regulation of negative emotion identified a widespread specific modulation of brain activation in regions subserving emotion generation and regulation as well as regions implicated in attention and default mode.

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Language(s): eng - English
 Dates: 2013-08-222013-03-032014-03-28
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0093098
PMID: 24682003
PMC: PMC3969367
Other: eCollection 2014
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 9 (3) Sequence Number: e93098 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850