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  Reward processing in obesity, substance addiction and non-substance addiction

Garcia-Garcia, I., Horstmann, A., Jurado, M. A., Garolera, M., Chaudhry, S. J., Margulies, D. S., et al. (2014). Reward processing in obesity, substance addiction and non-substance addiction. Obesity Reviews, 15(11), 853-869. doi:10.1111/obr.12221.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-2C35-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-142F-3
Genre: Journal Article

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 Creators:
Garcia-Garcia, Isabel1, 2, 3, Author              
Horstmann, Annette3, 4, Author              
Jurado, M. A.1, 2, 5, Author
Garolera, M.5, 6, Author
Chaudhry, S. J.7, Author
Margulies, Daniel S.8, Author              
Villringer, Arno3, 9, Author              
Neumann, Jane3, 4, Author              
Affiliations:
1Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, ou_persistent22              
2Institute for Brain, Cognition and Behaviour, Barcelona, Spain, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain, ou_persistent22              
6Neuropsychology Unit, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              
7Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, PA, USA, ou_persistent22              
8Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Body mass index (BMI); Brain; Food addiction; Reward
 Abstract: Similarities and differences between obesity and addiction are a prominent topic of ongoing research. We conducted an activation likelihood estimation meta-analysis on 87 studies in order to map the functional magnetic resonance imaging (fMRI) response to reward in participants with obesity, substance addiction and non-substance (or behavioural) addiction, and to identify commonalities and differences between them. Our study confirms the existence of alterations during reward processing in obesity, non-substance addiction and substance addiction. Specifically, participants with obesity or with addictions differed from controls in several brain regions including prefrontal areas, subcortical structures and sensory areas. Additionally, participants with obesity and substance addictions exhibited similar blood-oxygen-level-dependent fMRI hyperactivity in the amygdala and striatum when processing either general rewarding stimuli or the problematic stimuli (food and drug-related stimuli, respectively). We propose that these similarities may be associated with an enhanced focus on reward – especially with regard to food or drug-related stimuli – in obesity and substance addiction. Ultimately, this enhancement of reward processes may facilitate the presence of compulsive-like behaviour in some individuals or under some specific circumstances. We hope that increasing knowledge about the neurobehavioural correlates of obesity and addictions will lead to practical strategies that target the high prevalence of these central public health challenges.

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Language(s): eng - English
 Dates: 2014-07-142014-05-202014-07-212014-09-292014-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/obr.12221
PMID: 25263466
Other: Epub 2014
 Degree: -

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Title: Obesity Reviews
Source Genre: Journal
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Publ. Info: Oxford : Blackwell
Pages: - Volume / Issue: 15 (11) Sequence Number: - Start / End Page: 853 - 869 Identifier: ISSN: 1467-7881
CoNE: /journals/resource/1467-7881