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  Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine

Schoenberger, M., Damijonaitis, A., Zhang, Z., Nagel, D., & Trauner, D. (2014). Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine. ACS CHEMICAL NEUROSCIENCE, 5(7), 514-518. doi:10.1021/cn500070w.

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 Creators:
Schoenberger, Matthias1, Author
Damijonaitis, Arunas1, Author
Zhang, Zinan1, Author
Nagel, Daniel2, Author              
Trauner, Dirk1, Author
Affiliations:
1external, ou_persistent22              
2Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              

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Free keywords: GATED POTASSIUM CHANNELS; BLIND MICE; PHOTOSWITCH; TARGETS; NEURONS; PAINPhotopharmacology; local anesthetics; fomocaine; action potential firing control; azologization; azobenzene photoswitch;
 Abstract: Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the systematic conversion of an established drug into a photoswitchable one.

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Language(s): eng - English
 Dates: 2014-07
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000339226100006
DOI: 10.1021/cn500070w
 Degree: -

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Title: ACS CHEMICAL NEUROSCIENCE
Source Genre: Journal
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Publ. Info: 1155 16TH ST, NW, WASHINGTON, DC 20036 USA : AMER CHEMICAL SOC
Pages: - Volume / Issue: 5 (7) Sequence Number: - Start / End Page: 514 - 518 Identifier: ISSN: 1948-7193