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  A genome wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus

Cai, D., Fonteijn, H. M., Guadalupe, T., Zwiers, M., Wittfeld, K., Teumer, A., et al. (2014). A genome wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. Genes, Brain and Behavior, 13, 675-685. doi:10.1111/gbb.12157.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-C4E7-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-39AC-C
Genre: Journal Article

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 Creators:
Cai, Danchao1, 2, 3, Author              
Fonteijn, Hubert M.1, 3, Author              
Guadalupe, Tulio4, 5, Author              
Zwiers, Marcel3, 6, Author
Wittfeld, Katharina7, Author
Teumer, Alexander8, Author
Hoogman, Martine3, 4, 6, Author              
Arias Vásquez, Alejandro3, 6, Author
Yang, Yufang2, Author
Buitelaar, Jan3, 6, Author
Fernández, Guillén3, 6, Author
Brunner, Han G.3, 6, Author
Van Bokhoven, Hans3, 6, Author
Franke, Barbara3, 6, Author
Hegenscheid, Katrin9, Author
Homuth, Georg10, Author
Fisher, Simon E.3, 4, Author              
Grabe, Hans Jörgen7, 11, Author
Francks, Clyde3, 4, 12, Author              
Hagoort, Peter1, 3, Author              
Affiliations:
1Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_792551              
2Institute of Psychology, Chinese Academy of Sciences, Beijing, China, ou_persistent22              
3Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
4Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
5International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
6Departments of Human Genetics, Psychiatry and Cognitive Neuroscience, Radboud University Nijmegen Medical Centre,, Nijmegen, The Netherlands, ou_persistent22              
7German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              
8Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
9Institute for Radiology, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
10Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, ou_persistent22              
11Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Stralsund, Germany, ou_persistent22              
12Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              

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 Abstract: Heschl's gyrus (HG) is a core region of the auditory cortex whose morphology is highly variable across individuals. This variability has been linked to sound perception ability in both speech and music domains. Previous studies show that variations in morphological features of HG, such as cortical surface area and thickness, are heritable. To identify genetic variants that affect HG morphology, we conducted a genome-wide association scan (GWAS) meta-analysis in 3054 healthy individuals using HG surface area and thickness as quantitative traits. None of the single nucleotide polymorphisms (SNPs) showed association P values that would survive correction for multiple testing over the genome. The most significant association was found between right HG area and SNP rs72932726 close to gene DCBLD2 (3q12.1; P=2.77x10(-7)). This SNP was also associated with other regions involved in speech processing. The SNP rs333332 within gene KALRN (3q21.2; P=2.27x10(-6)) and rs143000161 near gene COBLL1 (2q24.3; P=2.40x10(-6)) were associated with the area and thickness of left HG, respectively. Both genes are involved in the development of the nervous system. The SNP rs7062395 close to the X-linked deafness gene POU3F4 was associated with right HG thickness (Xq21.1; P=2.38x10(-6)). This is the first molecular genetic analysis of variability in HG morphology

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Language(s): eng - English
 Dates: 20142014
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/gbb.12157
 Degree: -

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Title: Genes, Brain and Behavior
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Munksgaard
Pages: - Volume / Issue: 13 Sequence Number: - Start / End Page: 675 - 685 Identifier: ISSN: 1601-1848
CoNE: https://pure.mpg.de/cone/journals/resource/111006469467402