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  Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing Neurons in anxiety

Longo, A., Mele, P., Bertocchi, I., Oberto, A., Bachmann, A., Bartolomucci, A., et al. (2014). Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing Neurons in anxiety. Biological Psychiatry, 76(11), 840-849. doi:10.1016/j.biopsych.2014.01.009.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0023-C8C5-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-A509-5
Genre: Journal Article

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BiolPsychiatry_2014_ Jan 24. pii S0006-3223(14)00048-1e.pdf (Any fulltext), 4MB
 
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 Creators:
Longo, Angela, Author
Mele, Paolo, Author
Bertocchi, Ilaria, Author
Oberto, Alessandra, Author
Bachmann, Alessia, Author
Bartolomucci, Alessandro, Author
Palanza, Paola, Author
Sprengel, Rolf1, Author           
Eva, Carola, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Behavioral flexibility; conditional knockout mice; Cre-loxP system; GABA; hypothalamus-pituitary-adrenocortical axis; spatial memory
 Abstract: The Y1 receptor (Y1R) and Y5 receptor (Y5R) for neuropeptide Y share similar actions in the regulation of anxiety. Previously demonstrated that conditional removal of the Y1R during postnatal development in the forebrain excitatory neurons leads to higher anxiety, increased hypothalamus-pituitary-adrenocortical axis activity, and decreased body growth rate in male mice raised by foster mothers that exhibit high levels of maternal care. In the present study, we used the same conditional system to analyze the specific contribution to emotional behavior and stress response of the Y1R coexpressed with the Y5R.

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Language(s): eng - English
 Dates: 2014-01-132013-07-052014-01-142014-01-242014-12-01
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.biopsych.2014.01.009
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Title: Biological Psychiatry
  Other : Biol. Psychiatry
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 76 (11) Sequence Number: - Start / End Page: 840 - 849 Identifier: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111