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  Therapy-induced neuroplasticity of language in chronic post-stroke aphasia: A mismatch negativity study of (a)grammatical and meaningful/less mini-constructions

Lucchese, G., Pulvermüller, F., Stahl, B., Dreyer, F. R., & Mohr, B. (2017). Therapy-induced neuroplasticity of language in chronic post-stroke aphasia: A mismatch negativity study of (a)grammatical and meaningful/less mini-constructions. Frontiers in Human Neuroscience, 10: 669. doi:10.3389/fnhum.2016.00669.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-C8D6-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C518-4
Genre: Journal Article

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 Creators:
Lucchese, Guglielmo1, Author
Pulvermüller, Friedemann1, 2, Author
Stahl, Benjamin1, 3, 4, Author              
Dreyer, Felix R.1, Author
Mohr, Bettina5, Author
Affiliations:
1Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany, ou_persistent22              
2Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
3Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Department Psychiatry, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Cortical reorganization; Aphasia; Syntax; EEG; Intensive speech-language therapy; Mismatch negativity
 Abstract: Clinical language performance and neurophysiological correlates of language processing were measured before and after intensive language therapy in patients with chronic (time post stroke >1 year) post stroke aphasia (PSA). As event-related potential (ERP) measure, the mismatch negativity (MMN) was recorded in a distracted oddball paradigm to short spoken sentences. Critical ‘deviant’ sentence stimuli where either well-formed and meaningful, or syntactically, or lexico-semantically incorrect. After 4 weeks of speech-language therapy (SLT) delivered with high intensity (10.5 h per week), clinical language assessment with the Aachen Aphasia Test battery demonstrated significant linguistic improvements, which were accompanied by enhanced MMN responses. More specifically, MMN amplitudes to grammatically correct and meaningful mini-constructions and to ‘jabberwocky’ sentences containing a pseudoword significantly increased after therapy. However, no therapy-related changes in MMN responses to syntactically incorrect strings including agreement violations were observed. While MMN increases to well-formed meaningful strings can be explained both at the word and construction levels, the neuroplastic change seen for ‘jabberwocky’ sentences suggests an explanation in terms of constructions. The results confirm previous reports that intensive SLT leads to improvements of linguistic skills in chronic aphasia patients and now demonstrate that this clinical improvement is associated with enhanced automatic brain indexes of construction processing, although no comparable change is present for ungrammatical strings. Furthermore, the data confirm that the language-induced MMN is a useful tool to map functional language recovery in PSA.

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Language(s): eng - English
 Dates: 2016-04-132016-12-152017-01-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2016.00669
PMID: 28111545
PMC: PMC5216683
Other: eCollection 2016
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Funding organization : Freie Universität Berlin
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Funding organization : Charite - University Medicine Berlin
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Grant ID : PU 97/15-1 ; PU 97/16-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
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Funding program : -
Funding organization : Deutscher Akademischer Austauschdienst e.V.

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 669 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161