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Schlagwörter:
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Zusammenfassung:
The reaction of racemic 2-phenylpropanal with methyl- and n-butyllithium was studied in detail. Factors such as temperature, solvent, rate of addition, presence of salts, scale-up and source of reagents were carefully examined. Cram-selectivities of 90 –94% were routinely reached under standard conditions (THF, −78°C), which is significantly higher than previously reported for these classical reactions
