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  Obesity associated cerebral gray and white matter alterations are interrelated in the female brain

Mueller, K., Horstmann, A., Möller, H. E., Anwander, A., Lepsien, J., Schroeter, M. L., et al. (2014). Obesity associated cerebral gray and white matter alterations are interrelated in the female brain. PLoS One, 9(12): e114206. doi:10.1371/journal.pone.0114206.

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Mueller_2014_Obesity.pdf (Verlagsversion), 2MB
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 Urheber:
Mueller, Karsten1, Autor           
Horstmann, Annette2, 3, Autor           
Möller, Harald E.1, Autor           
Anwander, Alfred4, Autor           
Lepsien, Jöran1, Autor           
Schroeter, Matthias L.2, 5, Autor           
Villringer, Arno2, 3, 5, Autor           
Pleger, Burkhard2, 5, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Zusammenfassung: Obesity is known to affect the brain's gray matter (GM) and white matter (WM) structure but the interrelationship of such changes remains unclear. Here we used T1-weighted magnetic resonance imaging (MRI) in combination with voxel-based morphometry (VBM) and diffusion-tensor imaging (DTI) with tract-based spatial statistics (TBSS) to assess the relationship between obesity-associated alterations of gray matter density (GMD) and anisotropic water diffusion in WM, respectively. In a small cohort of lean to obese women, we confirmed previous reports of obesity-associated alterations of GMD in brain regions involved in executive control (i.e., dorsolateral prefrontal cortex, DLPFC) and habit learning (i.e., dorsal striatum). Gray matter density alterations of the DLPFC were negatively correlated with radial diffusivity in the entire corpus callosum. Within the genu of the corpus callosum we found a positive correlation with axial diffusivity. In posterior region and inferior areas of the body of the corpus callosum, axial diffusivity correlated negatively with altered GMD in the dorsal striatum. These findings suggest that, in women, obesity-related alterations of GMD in brain regions involved in executive control and habit learning might relate to alterations of associated WM fiber bundles within the corpus callosum.

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Sprache(n): eng - English
 Datum: 2014-03-192014-08-282014-12-10
 Publikationsstatus: Online veröffentlicht
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1371/journal.pone.0114206
PMID: 25494174
PMC: PMC4262391
Anderer: eCollection 2014
 Art des Abschluß: -

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Titel: PLoS One
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Science
Seiten: - Band / Heft: 9 (12) Artikelnummer: e114206 Start- / Endseite: - Identifikator: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850