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  The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone.

Yazdankhah, M., Farioli-Vecchioli, S., Tonchev, A. B., Stoykova, A., & Cecconi, F. (2014). The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell Death and Disease, 5: e1403. doi:10.1038/cddis.2014.358.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-D0CD-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CBD3-5
Genre: Journal Article

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 Creators:
Yazdankhah, M., Author
Farioli-Vecchioli, S., Author
Tonchev, A. B.1, Author              
Stoykova, A.1, Author              
Cecconi, F., Author
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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 Abstract: Autophagy is a conserved proteolytic mechanism required for maintaining cellular homeostasis. The role of this process in vertebrate neural development is related to metabolic needs and stress responses, even though the importance of its progression has been observed in a number of circumstances, both in embryonic and in postnatal differentiating tissues. Here we show that the proautophagic proteins Ambra1 and Beclin 1, involved in the initial steps of autophagosome formation, are highly expressed in the adult subventricular zone (SVZ), whereas their downregulation in adult neural stem cells in vitro leads to a decrease in cell proliferation, an increase in basal apoptosis and an augmented sensitivity to DNA-damage-induced death. Further, Beclin 1 heterozygosis in vivo results in a significant reduction of proliferating cells and immature neurons in the SVZ, accompanied by a marked increase in apoptotic cell death. In sum, we propose that Ambra1- and Beclin 1-mediated autophagy plays a crucial role in adult neurogenesis, by controlling the survival of neural precursor cells.

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Language(s): eng - English
 Dates: 2014-09-04
 Publication Status: Published online
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/cddis.2014.358
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Title: Cell Death and Disease
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: e1403 Start / End Page: - Identifier: -