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  In vivo measurement of partial oxygen pressure in vessels and in the reticuloendothelial system using fast 19F MRI

Nöth, U., Morrissey, S. P., Deichmann, R., Adolf, H., Schwarzbauer, C., Lutz, J., et al. (1995). In vivo measurement of partial oxygen pressure in vessels and in the reticuloendothelial system using fast 19F MRI. Magnetic Resonance in Medicine, 34(5), 738-745. doi:10.1002/mrm.1910340513.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-D4B9-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CAFA-E
Genre: Journal Article

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 Creators:
Nöth, Ulrike1, Author
Morrissey, Sean P.1, Author
Deichmann, Ralf1, Author
Adolf, Holger1, Author
Schwarzbauer, Christian1, Author              
Lutz, Joachim1, Author
Haase, Axel1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: 19F-MRI; Partial oxygen pressure (pO2); Blood vessels; reticuloendothelial system
 Abstract: Quantitative in vivo 19F-MRI was performed in a rat model to monitor partial oxygen pressure (pO2) using a perfluorocarbon (PFC) emulsion as contrast agent. On Days 1, 4, and 8 postinjection of the PFC emulsion, transaxial T1 and pO2 maps were acquired of the abdomen of rats that were consecutively ventilated with pure oxygen, air, and a mixture of 10% oxygen and 90% nitrogen. The images had a resolution of 0.75 mm x 0.75 mm x 2 mm and a total acquisition time of 24 min. In these images it was possible to distinguish between different vessels and hepatic and splenic tissue in the selected imaging plane. Serial 19F-MRI measurements on the different days postinjection of the PFC allowed to determine separately the pO2 of arterial and venous blood and the intracellular pO2 in macrophages of the liver and spleen.

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Language(s): eng - English
 Dates: 1995-06-132005-11-211995
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.1910340513
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 34 (5) Sequence Number: - Start / End Page: 738 - 745 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149