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  Converging circuits mediate temperature and shock aversive olfactory conditioning in Drosophila

Galili, D. S., Dylla, K. V., Luedke, A., Friedrich, A. B., Yamagata, N., Wong, J. Y. H., et al. (2014). Converging circuits mediate temperature and shock aversive olfactory conditioning in Drosophila. Current Biology, 24(15), 1712-1722. doi:10.1016/j.cub.2014.06.062.

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 Creators:
Galili, Dana Shani1, Author           
Dylla, Kristina V., Author
Luedke, Alja, Author
Friedrich, Anja B., Author
Yamagata, Nobuhiro, Author
Wong, Jin Yan Hilary1, Author           
Ho, Chien Hsien1, Author           
Szyszka, Paul, Author
Tanimoto, Hiromu1, Author           
Affiliations:
1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              

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Free keywords: DOPAMINERGIC-NEURONS; SYNAPTIC-TRANSMISSION; TYROSINE-HYDROXYLASE; REWARD; NOCICEPTION; EXPRESSION; MEMORY; GENE; MELANOGASTER; PUNISHMENT
 Abstract: Background: Drosophila learn to avoid odors that are paired with aversive stimuli. Electric shock is a potent aversive stimulus that acts via dopamine neurons to elicit avoidance of the associated odor. While dopamine signaling has been demonstrated to mediate olfactory electric shock conditioning, it remains unclear how this pathway is involved in other types of behavioral reinforcement, such as in learned avoidance of odors paired with increased temperature.
Results: To better understand the neural mechanisms of distinct aversive reinforcement signals, we here established an olfactory temperature conditioning assay comparable to olfactory electric shock conditioning. We show that the AC neurons, which are internal thermal receptors expressing dTrpA1, are selectively required for odor-temperature but not for odor-shock memory. Furthermore, these separate sensory pathways for increased temperature and shock converge onto overlapping populations of dopamine neurons that signal aversive reinforcement. Temperature conditioning appears to require a subset of the dopamine neurons required for electric shock conditioning.
Conclusions: We conclude that dopamine neurons integrate different noxious signals into a general aversive reinforcement pathway.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000340074100018
DOI: 10.1016/j.cub.2014.06.062
 Degree: -

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Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 24 (15) Sequence Number: - Start / End Page: 1712 - 1722 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107