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  Histone supply regulates S phase timing and cell cycle progression.

Günesdogan, U., Jäckle, H., & Herzig, A. (2014). Histone supply regulates S phase timing and cell cycle progression. eLife, 3: e02443. doi:10.7554/eLife.02443.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-E4CB-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6DE3-D
Genre: Journal Article

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 Creators:
Günesdogan, U., Author
Jäckle, H.1, Author              
Herzig, A.1, Author              
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1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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 Abstract: Eukaryotes package DNA into nucleosomes that contain a core of histone proteins. During DNA replication, nucleosomes are disrupted and re-assembled with newly synthesized histones and DNA. Despite much progress, it is still unclear why higher eukaryotes contain multiple core histone genes, how chromatin assembly is controlled, and how these processes are coordinated with cell cycle progression. We used a histone null mutation of Drosophila melanogaster to show that histone supply levels, provided by a defined number of transgenic histone genes, regulate the length of S phase during the cell cycle. Lack of de novo histone supply not only extends S phase, but also causes a cell cycle arrest during G2 phase, and thus prevents cells from entering mitosis. Our results suggest a novel cell cycle surveillance mechanism that monitors nucleosome assembly without involving the DNA repair pathways and exerts its effect via suppression of CDC25 phosphatase String expression.

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Language(s): eng - English
 Dates: 2014-09-09
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.02443
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Title: eLife
Source Genre: Journal
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Pages: 19 Volume / Issue: 3 Sequence Number: e02443 Start / End Page: - Identifier: -