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  Shared mushroom body circuits underlie visual and olfactory memories in Drosophila

Vogt, K., Schnaitmann, C., Dylla, K. V., Knapek, S., Aso, Y., Rubin, G. M., et al. (2014). Shared mushroom body circuits underlie visual and olfactory memories in Drosophila. eLife, 3: e02395. doi:10.7554/eLife.02395.

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Shared mushroom body circuits underlie visual and olfactory memories in Drosophila.pdf
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Vogt, Katrin1, Author           
Schnaitmann, Christopher1, Author           
Dylla, Kristina V.1, Author           
Knapek, Stephan1, Author           
Aso, Yoshinori, Author
Rubin , Gerald M., Author
Tanimoto, Hiromu1, Author           
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1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              

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Free keywords: TARGETED GENE-EXPRESSION; HONEYBEE APIS-MELLIFERA; STING EXTENSION REFLEX; SHORT-TERM-MEMORY; COLOR DISCRIMINATION; DOPAMINERGIC-NEURONS; MUTANT DROSOPHILA; AVERSIVE MEMORY; NEURAL CIRCUITS; ODOR MEMORY
 Abstract: In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila that are comparable to the widely used olfactory learning assays. These assays share critical features, such as reinforcing stimuli (sugar reward and electric shock punishment), and allow direct comparison of the cellular requirements for visual and olfactory memories. We found that the same subsets of dopamine neurons drive formation of both sensory memories. Furthermore, distinct yet partially overlapping subsets of mushroom body intrinsic neurons are required for visual and olfactory memories. Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs.

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Language(s): eng - English
 Dates: 2014-08-19
 Publication Status: Published in print
 Pages: 22
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000341253500004
DOI: 10.7554/eLife.02395
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 3 Sequence Number: e02395 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X