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  Serotonergic modulation of intrinsic functional connectivity

Schäfer, A., Burmann, I., Regenthal, R., Arélin, K., Barth, C., Pampel, A., et al. (2014). Serotonergic modulation of intrinsic functional connectivity. Current Biology, 24(19), 2314-2318. doi:10.1016/j.cub.2014.08.024.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-EDB3-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-81BB-8
Genre: Journal Article

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 Creators:
Schäfer, Alexander1, 2, Author              
Burmann, Inga1, Author              
Regenthal, Ralf3, Author
Arélin, Katrin1, 4, 5, Author              
Barth, Claudia1, Author
Pampel, André6, Author              
Villringer, Arno1, 4, 5, 7, 8, Author              
Margulies, Daniel S.8, 9, Author              
Sacher, Julia1, 4, 8, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Electrical and Computer Engineering, Clinical Imaging Research Centre & Singapore Institute for Neurotechnology, National University of Singapore, Singapore, ou_persistent22              
3Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
9Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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Free keywords: Prefrontal cortex; Brain; Citalopram; Antidepressants; Depression; Neurons; Fluctuations; Escitalopram; Projections; Thalamus
 Abstract: Serotonin functions as an essential neuromodulator that serves a multitude of roles, most prominently balancing mood [1]. Serotonergic challenge has been observed to reduce intrinsic functional connectivity in brain regions implicated in mood regulation [2-4]. However, the full scope of serotonergic action on functional connectivity in the human brain has not been explored. Here, we show evidence that a single dose of a serotonin reuptake inhibitor dramatically alters functional connectivity throughout the whole brain in healthy subjects (n = 22). Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas. In the cerebellum and thalamus, however, we find localized increases. These rapid and brain-encompassing connectivity changes linked to acute serotonin transporter blockade suggest a key role for the serotonin transporter in the modulation of the functional macroscale connectome.

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Language(s): eng - English
 Dates: 2014-06-302014-04-082014-08-132014-09-182014-10-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cub.2014.08.024
PMID: 25242032
Other: Epub 2014
 Degree: -

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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 24 (19) Sequence Number: - Start / End Page: 2314 - 2318 Identifier: ISSN: 0960-9822
CoNE: /journals/resource/954925579107