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  Copy number variants and selective sweeps in natural populations of the house mouse (Mus musculus domesticus)

Bryk, J., & Tautz, D. (2014). Copy number variants and selective sweeps in natural populations of the house mouse (Mus musculus domesticus). Frontiers in Genetics, 5(153): 153. doi:10.3389/fgene.2014.00153.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-F51B-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-F7DF-4
Genre: Journal Article

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Bryk, Jarosłav1, Author              
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: CNV; selectivesweeps; mice; CGHmicroarray; naturalpopulations
 Abstract: Copy–numbervariants(CNVs)mayplayanimportantroleinearlyadaptations,potentiallyfacilitatingrapiddivergenceofpopulations.WedescribeanapproachtostudythisquestionbyinvestigatingCNVspresentinnaturalpopulationsofmiceintheearlystagesofdivergenceandtheirinvolvementinselectivesweeps.Wehaveanalyzedindividualsfromtworecentlydivergednaturalpopulationsofthehousemouse(Musmusculusdomesticus)fromGermanyandFranceusingcustom,high–density,comparativegenomehybridizationarrays(CGH)thatcoveredalmost164Mband2444genes.Onethousandeighthundredandsixtyoneofthosegeneswepreviouslyidentifiedasdifferentiallyexpressedbetweenthesepopulations,whiletheexpressionoftheremaininggeneswasinvariant.Intotal,weidentified1868CNVsacrossall10samples,200bpto600kbinsizeandaffecting424genicregions.RoughlytwothirdsofallCNVsfoundweredeletions.WefoundnoenrichmentofCNVsamongthedifferentiallyexpressedgenesbetweenthepopulationscomparedtotheinvariantones,noranymeaningfulcorrelationbetweenCNVsandgeneexpressionchanges.AmongtheCNVgenes,wefoundcellularcomponentgeneontologycategoriesofthesynapseoverrepresentedamongallthe2444genestested.ToinvestigatepotentialadaptivesignificanceoftheCNVregions,weselectedsixthatshowedlargedifferencesinfrequencyofCNVsbetweenthetwopopulationsandanalyzedvariationinatleasttwomicrosatellitessurroundingthelociinasampleof46unrelatedanimalsfromthesamepopulationscollectedinfieldtrappings.Weidentifiedtwolociwithlargedifferencesinmicrosatelliteheterozygosity(Sfi1andGlo1/Dnahc8regions)andonelocuswithlowvariationacrossthepopulations(Cmah),thussuggestingthatthesegenomicregionsmighthaverecentlyundergoneselectivesweeps.Interestingly,theGlo1CNVhaspreviouslybeenimplicatedinanxiety–likebehaviorinmice,suggestingadifferentialevolutionofabehavioraltrait.

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Language(s): eng - English
 Dates: 2013-12-022014-05-092014-06-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fgene.2014.00153
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Title: Frontiers in Genetics
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: 9 S. Volume / Issue: 5 (153) Sequence Number: 153 Start / End Page: - Identifier: ISSN: 1664-8021
CoNE: /journals/resource/1664-8021