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  Macromolecular complexes at active zones: Integrated nano-machineries for neurotransmitter release.

Chua, J. J. (2014). Macromolecular complexes at active zones: Integrated nano-machineries for neurotransmitter release. Cellular and Molecular Life Sciences, 71(20), 3903-3916. doi:10.1007/s00018-014-1657-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-0399-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CCBD-2
Genre: Journal Article

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2065735.pdf (Publisher version), 2MB
 
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 Creators:
Chua, J. J.1, Author              
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1Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              

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Free keywords: Synaptic transmission; Presynaptic nerve terminal; Active zone; Presynaptic proteins; Neuroproteomics
 Abstract: The release of neurotransmitters from synaptic vesicles exocytosing at presynaptic nerve terminals is a critical event in the initiation of synaptic transmission. This event occurs at specialized sites known as active zones. The task of faithfully executing various steps in the process is undertaken by careful orchestration of overlapping sets of molecular nano-machineries upon a core macromolecular scaffold situated at active zones. However, their composition remains incompletely elucidated. This review provides an overview of the role of the active zone in mediating neurotransmitter release and summarizes the recent progress using neuroproteomic approaches to decipher their composition. Key proteins of these nano-machineries are highlighted.

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Language(s): eng - English
 Dates: 2014-06-102014-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00018-014-1657-5
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Title: Cellular and Molecular Life Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 71 (20) Sequence Number: - Start / End Page: 3903 - 3916 Identifier: -