ausblenden:
Schlagwörter:
furan, palladium, sulfur ylide, terpene, marine natural product
Zusammenfassung:
A flexible entry into 2,4-disubstituted furan derivatives is outlined employing sulfonium salt 1 as a well accessible starting material. Condensation of the sulfur ylide derived from 1 with alde-hydes, palladium catalyzed opening of the vinyloxirane thus formed, and a final oxidative cyclization of the furan ring constitute the key steps of this method. Its utility is exemplified by the first to-tal synthesis of the marine natural product ircinin-4 (2).
