English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning

Andreescu, C. E., Prestori, F., Brandalise, F., D´Errico, A., De Jeu, M. T. G., Rossi, P., et al. (2011). NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning. Neuroscience, 176, 274-283. doi:10.1016/j.neuroscience.2010.12.024.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning

Files

show Files
hide Files
:
Neurosci_176_2011_274.pdf (Any fulltext), 634KB
 
File Permalink:
-
Name:
Neurosci_176_2011_274.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Andreescu, C. E., Author
Prestori, F., Author
Brandalise, F., Author
D´Errico, A., Author
De Jeu, M. T. G., Author
Rossi, Paola, Author
Botta, L., Author
Köhr, Georg1, Author              
Perin, P., Author
D´Angelo, Egidio, Author
De Zeeuw, C. I., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: Traditionally studies aimed at elucidating the molecular mechanisms underlying cerebellar motor learning have been focused on plasticity at the parallel fiber to Purkinje cell synapse. In recent years, however, the concept is emerging that formation and storage of memories are both distributed over multiple types of synapses at different sites. Here, we examined the potential role of potentiation at the mossy fiber to granule cell synapse, which occurs upstream to plasticity in Purkinje cells. We show that null−mutants of N−methyl D−aspartate−NR2A receptors (NMDA−NR2A/ mice) have impaired induction of postsynaptic long−term potentiation (LTP) at the mossy fiber terminals and a reduced ability to raise the granule cell synaptic excitation, while the basic excitatory output of the mossy fibers is unaffected. In addition, we demonstrate that these NR2A/ mutants as well as mutants in which the C terminal in the NR2A subunit is selectively truncated (NR2AC/C mice) have deficits in phase reversal adaptation of their vestibulo−ocular reflex (VOR), while their basic eye movement performance is similar to that of wild type littermates. These results indicate that NMDANR2A mediated potentiation at the mossy fiber to granule cell synapse is not required for basic motor performance, and they raise the possibility that it may contribute to some forms of vestibulo−cerebellar memory formation

Details

show
hide
Language(s): eng - English
 Dates: 2010-12-152010-12-232011-03-10
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664510
DOI: 10.1016/j.neuroscience.2010.12.024
Other: 7658
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 176 Sequence Number: - Start / End Page: 274 - 283 Identifier: ISSN: 0306-4522
CoNE: https://pure.mpg.de/cone/journals/resource/954925514498