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  Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care

Bertocchi, I., Oberto, A., Longo, A., Mele, P., Sabetta, M., Bartolomucci, A., et al. (2011). Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19395-19400. doi:10.1073/pnas.1109468108.

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Genre: Journal Article
Alternative Title : Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care

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PNAS_108_2011_19395.pdf (Any fulltext), 992KB
 
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 Creators:
Bertocchi, Ilaria1, Author              
Oberto, Alessandra, Author
Longo, Angela, Author
Mele, Paolo1, Author              
Sabetta, Marianna, Author
Bartolomucci, Alessandro, Author
Palanza, Paola, Author
Sprengel, Rolf1, Author              
Eva, Carola, Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Neuropeptide Y (NPY) plays an important role in stress, anxiety, obesity, and energy homeostasis via activation of NPY−Y1 receptors (Y1Rs) in the brain. However, global knockout of the Npy1r gene has low or no impact on anxiety and body weight. To uncover the role of limbic Y1Rs, we generated conditional knockout mice in which the inactivation of the Npy1r gene was restricted to excitatory neurons of the forebrain, starting from juvenile stages (Npy1rrfb). Npy1rrfb mice exhibited increased anxiety and reduced body weight, less adipose tissue, and lower serum leptin levels. Npy1rrfb mutants also had a hyperactive hypothalamic−pituitary−adrenocortical axis, as indicated by higher peripheral corticosterone and higher density of NPY immunoreactive fibers and corticotropin releasing hormone immunoreactive cell bodies in the paraventricular hypothalamic nucleus. Importantly, through fostering experiments, we determined that differences in phenotype between Npy1rrfb and Npy1r2lox mice became apparent when both genotypes were raised by FVB/J but not by C57BL/6J dams, suggesting that limbic Y1Rs are key targets of maternal care−induced programming of anxiety and energy homeostasis

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Language(s): eng - English
 Dates: 2011-06-232011-10-132011-11-29
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664460
DOI: 10.1073/pnas.1109468108
Other: 7710
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 108 (48) Sequence Number: - Start / End Page: 19395 - 19400 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230