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  Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice

Grinevich, V., Jezova, D., Gambaryan, S., Illarionova, A., Kolleker, A., Seeburg, P. H., et al. (2011). Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice. Hormone and metabolic research = Hormon− und Stoffwechselforschung = Hormones et métabolisme, 43(8), 551-556. doi:10.1055/s-0031-1280828.

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Genre: Journal Article
Alternative Title : Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice

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 Creators:
Grinevich, V.1, Author              
Jezova, D., Author
Gambaryan, S., Author
Illarionova, A.1, Author              
Kolleker, A.1, Author              
Seeburg, Peter H.1, Author              
Schwarz, Martin K.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: adrenal cortex − glucocorticoids − HPA−axis − aldosterone
 Abstract: Homer 1 gene products are involved in synaptic transmission and plasticity, and hence, distinct behavioral abnormalities, including anxiety− and depression−like behaviors, have been observed in Homer 1 knockout (KO) mice. Here we report that Homer 1 KO mice additionally exhibit a pronounced endocrine phenotype, displaying a profoundly increased adrenal gland weight and increased adrenal/body weight ratio. Histological examinations of Homer 1 deficient adrenal glands revealed an increased size of the adrenal cortex, especially the sizes of the zona fasciculata and zona glomerulosa. Moreover, the plasma corticosterone and aldosterone were higher in Homer 1 KO than wild−type (WT) mice while the plasma ACTH levels were not different between the genotypes. The in vivo ACTH test revealed that corticosterone and aldosterone plasma levels were higher in saline injected Homer 1 KO mice than in WT mice (saline injected mice served as controls for the respective groups of ACTH−injected animals), but the magnitude of steroid responses to ACTH was similar in both genotypes. In contrast, an in vitro experiment performed on isolated cells of adrenal cortex clearly showed increased production of both steroids in response to ACTH in Homer 1 KO cells, which is in line with an ˜8−fold increase in the expression of ACTH receptor mRNA in the adrenal cortex of these mutants. These results, together with the detection of Homer 1 mRNA and protein in the adrenal cortex of WT mice, indicate that Homer 1 directly affects the steroidogenic function of the adrenal glands

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Language(s): eng - English
 Dates: 2011-07-19
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664483
DOI: 10.1055/s-0031-1280828
Other: 7717
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Title: Hormone and metabolic research = Hormon− und Stoffwechselforschung = Hormones et métabolisme
  Alternative Title : Hormone and metabolic research = Hormon− und Stoff
Source Genre: Journal
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Pages: - Volume / Issue: 43 (8) Sequence Number: - Start / End Page: 551 - 556 Identifier: ISSN: 0018-5043