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  Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum

Gabriel, J. P., Trivedi, C., Maurer, C., Ryu, S., & Bollmann, J. H. (2012). Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum. Neuron, 76(6), 1147-1160. doi:10.1016/j.neuron.2012.12.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-12A8-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-12A9-2
Genre: Journal Article
Alternative Title : Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum

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 Creators:
Gabriel, Jens Peter1, Author              
Trivedi, Chintan1, Author              
Maurer, Colette2, Author              
Ryu, Soojin2, Author              
Bollmann, Johann H.1, Author              
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Max Planck Research Group Developmental Genetics of the nervous system (Soojin Ryu), Max Planck Institute for Medical Research, Max Planck Society, ou_1497724              

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 Abstract: Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca2+ imaging in cells expressing the genetically encoded Ca2+ indicator GCaMP3 and multiphoton−targeted patch−clamp recordings allowed us to compare structure and function in single neurons. The arbors of differently tuned cell types showed stereotypic differences in shape and laminar profile within the tectal neuropil. Excitatory synaptic inputs were directionally tuned and matched the PD of spike output in these cells, while inhibitory inputs were selective for nonpreferred directions. Functional Ca2+ imaging in afferent axons showed a matching laminar distribution of DS presynaptic activity. Hence, different directions are represented in different layers, which suggests a simple mechanism for how tectal neurons acquire directional tuning in a nascent circuit

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Language(s): eng - English
 Dates: 2012-12-032012-12-192012-12-20
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 76 (6) Sequence Number: - Start / End Page: 1147 - 1160 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565