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  Homer 1 - a new player linking the hypothalamic-pituitary-adrenal axis activity to depression and anxiety.

Grinevich, V., Seeburg, P. H., Schwarz, M. K., & Jezova, D. (2012). Homer 1 - a new player linking the hypothalamic-pituitary-adrenal axis activity to depression and anxiety. Endocrine Regulations, 46(3), 153-159. doi:10.4149/endo_2012_03_153.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1302-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-130C-9
Genre: Journal Article
Alternative Title : Homer 1 - a new player linking the hypothalamic-pituitary-adrenal axis activity to depression and anxiety.

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EndocrinRegulat_46_2012_153.pdf (Any fulltext), 648KB
 
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 Creators:
Grinevich, Valery1, Author              
Seeburg, Peter H.1, Author              
Schwarz, Martin K.1, Author              
Jezova, Daniela, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Homer 1, HPA axis, CRH, ACTH, adrenal cortex, corticosterone, aldosterone
 Abstract: Homer 1 gene products are involved in the regulation of synaptic transmission and plasticity. Beside other deficits, the Homer 1 knockout (KO) mice show distinct behavioural abnormalities, such as anxiety and depression−like behaviours. In addition, we recently reported that the global deletion of the Homer 1 proteins in mice leads to a conspicuous endocrine phenotype linked to hypertrophy of the adrenal cortex, elevated basal and/or adrenocorticotropic hormone−induced corticosterone and aldosterone release in vitro and in vivo, as well as a drastic increase in the adrenocorticotropic hormone receptor mRNA in the adrenocortical cells. Interestingly, the basal secretion of adrenocorticotropic hormone was not changed in these mutants, which is in line with our recent observations, suggesting that the central limb of the hypothalamic−pituitary−adrenal axis (namely hypothalamic corticotropin−releasing hormone levels and the activation of its neurons in response to restraint stress) is not affected in the Homer 1 KO mice. On the contrary, the elevation of both plasma and intra−adrenal corticosterone and aldosterone concentrations in these mutants clearly indicates that the alteration primarily occurred in the adrenal cortex. We propose that excessive steroid release may contribute to depression− and anxiety−like behaviours and that the Homer 1 gene products may be involved in the pathogenesis of these stress−related mood disorders

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Language(s): eng - English
 Dates: 2012-07-01
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Endocrine Regulations
  Alternative Title : Endocrine Regulations
Source Genre: Journal
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Publ. Info: Bratislava, Slovak Republic : AEPress, s.r.o. Bajzova 7 821 08 Bratislava, Slovak Republic
Pages: - Volume / Issue: 46 (3) Sequence Number: - Start / End Page: 153 - 159 Identifier: ISSN: 1210-0668