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  Real-time phase-contrast flow MRI of the ascending aorta and superior vena cava as a function of intrathoracic pressure (Valsalva manoeuvre).

Kowallick, J. T., Joseph, A. A., Unterberg-Buchwald, C., Fasshauer, M., Van Wijk, K., Merboldt, K. D., et al. (2014). Real-time phase-contrast flow MRI of the ascending aorta and superior vena cava as a function of intrathoracic pressure (Valsalva manoeuvre). British Journal of Radiology, 87(1042): 20140401. doi:10.1259/bjr.20140401.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1DC7-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-BBC1-8
Genre: Journal Article

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 Creators:
Kowallick, J. T., Author
Joseph, A. A., Author
Unterberg-Buchwald, C., Author
Fasshauer, M., Author
Van Wijk, K., Author
Merboldt, K. D.1, Author              
Voit, D.1, Author              
Frahm, J.1, Author              
Lotz, J., Author
Sohns, J. M., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: Objective: Real-time phase-contrast flow MRI at high spatiotemporal resolution was applied to simultaneously evaluate haemodynamic functions in the ascending aorta (AA) and superior vena cava (SVC) during elevated intrathoracic pressure (Valsalva manoeuvre). Methods: Real-time phase-contrast flow MRI at 3 T was based on highly undersampled radial gradient-echo acquisitions and phase-sensitive image reconstructions by regularized non-linear inversion. Dynamic alterations of flow parameters were obtained for 19 subjects at 40-ms temporal resolution, 1.33-mm in-plane resolution and 6-mm section thickness. Real-time measurements were performed during normal breathing (10 s), increased intrathoracic pressure (10 s) and recovery (20 s). Results: Real-time measurements were technically successful in all volunteers. During the Valsalva manoeuvre (late strain) and relative to values during normal breathing, the mean peak flow velocity and flow volume decreased significantly in both vessels (p < 0.001) followed by a return to normal parameters within the first 10 s of recovery in the AA. By contrast, flow in the SVC presented with a brief (1-2 heartbeats) but strong overshoot of both the peak velocity and blood volume immediately after pressure release followed by rapid normalization. Conclusion: Real-time phase-contrast flow MRI may assess cardiac haemodynamics non-invasively, in multiple vessels, across the entire luminal area and at high temporal and spatial resolution. Advances in knowledge: Future clinical applications of this technique promise new insights into haemodynamic alterations associated with pre-clinical congestive heart failure or diastolic dysfunction, especially in cases where echocardiography is technically compromised.

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Language(s): eng - English
 Dates: 2014-10
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1259/bjr.20140401
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Title: British Journal of Radiology
Source Genre: Journal
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Pages: 7 Volume / Issue: 87 (1042) Sequence Number: 20140401 Start / End Page: - Identifier: -