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  Ion permeation in K+ channels occurs by direct Coulomb knock-on.

Köpfer, D., Song, C., Gruene, T., Sheldrick, G. M., Zachariae, U., & de Groot, B. L. (2014). Ion permeation in K+ channels occurs by direct Coulomb knock-on. Science, 345(6207), 352-355. doi:10.1126/science.1254840.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1DFA-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CDE5-9
Genre: Journal Article

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 Creators:
Köpfer, D.1, Author              
Song, C., Author
Gruene, T., Author
Sheldrick, G. M., Author
Zachariae, U., Author
de Groot, B. L.1, Author              
Affiliations:
1Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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 Abstract: Potassium channels selectively conduct K+ ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K+ concentrations, previously thought to reflect a superposition of alternating ion-and water-occupied states. Consequently, cotranslocation of ions with water has become a widely accepted ion conduction mechanism for potassium channels. By analyzing more than 1300 permeation events from molecular dynamics simulations at physiological voltages, we observed instead that permeation occurs via ion-ion contacts between neighboring K+ ions. Coulomb repulsion between adjacent ions is found to be the key to high-efficiency K+ conduction. Crystallographic data are consistent with directly neighboring K+ ions in the selectivity filter, and our model offers an intuitive explanation for the high throughput rates of K+ channels.

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Language(s): eng - English
 Dates: 2014-10-17
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.1254840
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 345 (6207) Sequence Number: - Start / End Page: 352 - 355 Identifier: -