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  Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A

Meyer, H. S., Schwarz, D., Wimmer, V. C., Schmitt, A. C., Kerr, J. N. D., Sakmann, B., et al. (2011). Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16807-16812. doi:10.1073/pnas.1113648108.

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Genre: Journal Article
Alternative Title : Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A

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Meyer, Hanno S., Author
Schwarz, Daniel1, Author           
Wimmer, Verena C.2, Author           
Schmitt, Arno C.2, Author           
Kerr, Jason N. D., Author
Sakmann, Bert2, Author           
Helmstaedter, Moritz2, 3, Author           
Affiliations:
1Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
3Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: barrel cortex | parvalbumin | somatostatin | calretinin
 Abstract: Although physiological data on microcircuits involving a few inhibitory neurons in the mammalian cerebral cortex are available, data on the quantitative relation between inhibition and excitation in cortical circuits involving thousands of neurons are largely missing. Because the distribution of neurons is very inhomogeneous in the cerebral cortex, it is critical to map all neurons in a given volume rather than to rely on sparse sampling methods. Here, we report the comprehensive mapping of interneurons (INs) in cortical columns of rat somatosensory cortex, immunolabeled for neuron−specific nuclear protein and glutamate decarboxylase. We found that a column contains ˜2,200 INs (11.5% of ˜19,000 neurons), almost a factor of 2 less than previously estimated. The density of GABAergic neurons was inhomogeneous between layers, with peaks in the upper third of L2/3 and in L5A. IN density therefore defines a distinct layer 2 in the sensory neocortex. In addition, immunohistochemical markers of IN subtypes were layer−specific. The

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Language(s): eng - English
 Dates: 2011-04-212011-08-242011-10-04
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664452
DOI: 10.1073/pnas.1113648108
Other: 7726
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 108 (40) Sequence Number: - Start / End Page: 16807 - 16812 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230