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  Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex

Oberlaender, M., de Kock, C. P. J., Bruno, R. M., Ramirez, A., Meyer, H. S., Dercksen, V. J., et al. (2012). Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex. Cerebral Cortex, 22(10), 2375-2391. doi:10.1093/cercor/bhr317.

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Genre: Journal Article
Alternative Title : Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex

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 Creators:
Oberlaender, Marcel1, Author           
de Kock, Christiaan P. J., Author
Bruno, Randy M., Author
Ramirez, Alejandro, Author
Meyer, Hanno S., Author
Dercksen, Vincent J., Author
Helmstaedter, Moritz2, Author           
Sakmann, Bert3, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497699              
3Emeritus Group: Cortical Column in silico / Sakmann, MPI of Neurobiology, Max Planck Society, ou_1113549              

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Free keywords: barrel cortex dendrite morphology in vivo spiking neural network VPM innervation
 Abstract: Soma location, dendrite morphology, and synaptic innervation may represent key determinants of functional responses of individual neurons, such as sensory−evoked spiking. Here, we reconstruct the 3D circuits formed by thalamocortical afferents from the lemniscal pathway and excitatory neurons of an anatomically defined cortical column in rat vibrissal cortex. We objectively classify 9 cortical cell types and estimate the number and distribution of their somata, dendrites, and thalamocortical synapses. Somata and dendrites of most cell types intermingle, while thalamocortical connectivity depends strongly upon the cell type and the 3D soma location of the postsynaptic neuron. Correlating dendrite morphology and thalamocortical connectivity to functional responses revealed that the lemniscal afferents can account for some of the cell type− and location−specific subthreshold and spiking responses after passive whisker touch (e.g., in layer 4, but not for other cell types, e.g., in layer 5). Our data provides a quantitative 3D prediction of the cell type−specific lemniscal synaptic wiring diagram and elucidates structure−function relationships of this physiologically relevant pathway at single−cell resolution

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Language(s): eng - English
 Dates: 2011-11-162012-10-01
 Publication Status: Published in print
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 Rev. Type: Peer
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 22 (10) Sequence Number: - Start / End Page: 2375 - 2391 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440