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  Noradrenergic ‘Tone' determines dichotomous control of cortical spike-timing-dependent plasticity

Salgado, H., Köhr, G., & Trevino, M. (2012). Noradrenergic ‘Tone' determines dichotomous control of cortical spike-timing-dependent plasticity. Scientific Reports, 2: 417, pp. 1-7. doi:10.1038/srep00417.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1EFA-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1EFB-C
Genre: Journal Article
Alternative Title : Noradrenergic ‘Tone' determines dichotomous control of cortical spike-timing-dependent plasticity

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ScientificRep_2_2012_417e_1.pdf (Any fulltext), 493KB
 
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 Creators:
Salgado, Humberto, Author
Köhr, Georg1, Author              
Trevino, Mario1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Norepinephrine (NE) is widely distributed throughout the brain. It modulates intrinsic currents, as well as amplitude and frequency of synaptic transmission affecting the ‘signal−to−noise ratio' of sensory responses. In the visual cortex, a1− and b−adrenergic receptors (AR) gate opposing effects on long−term plasticity of excitatory transmission. Whether and how NE recruits these plastic mechanisms is not clear. Here, we show that NE modulates glutamatergic inputs with different efficacies for a1− and b−AR. As a consequence, the priming of synapses with different NE concentrations produces dose−dependent competing effects that determine the temporal window of spike−timing dependent plasticity (STDP). While a low NE concentration leads to long−term depression (LTD) over broad positive and negative delays, a high NE concentration results in bidirectional STDP restricted to very narrow intervals. These results indicate that the local availability of NE, released during emotional arousal, determines the compound modulatory effect and the output of STDP

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Language(s): eng - English
 Dates: 2012-04-102012-05-092012-05-232012-05-23
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 2 Sequence Number: 417 Start / End Page: 1 - 7 Identifier: Other: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322