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  Psychophysical properties of odor processing can be quantitatively described by relative action potential latency patterns in mitral and tufted cells

Schaefer, A. T., & Margrie, T. W. (2012). Psychophysical properties of odor processing can be quantitatively described by relative action potential latency patterns in mitral and tufted cells. Frontiers in Systems Neuroscience, 6: e30, pp. 1-8. doi:10.3389/fnsys.2012.00030.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1F2C-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1F2D-5
Genre: Journal Article
Alternative Title : Psychophysical properties of odor processing can be quantitatively described by relative action potential latency patterns in mitral and tufted cells

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 Creators:
Schaefer, Andreas T.1, Author              
Margrie, Troy W.1, 2, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: model, latency code, olfaction, discrimination times, in vivo, behavior
 Abstract: Electrophysiological and population imaging data in rodents show that olfactory bulb (OB) activity is profoundly modulated by the odor sampling process while behavioral experiments indicate that odor discrimination can occur within a single sniff. This paper addresses the question of whether action potential (AP) latencies occurring across the mitral and tufted cell (M/TC) population within an individual sampling cycle could account for the psychophysical properties of odor processing. To determine this we created an OB model (50,000 M/TCs) exhibiting hallmarks of published in vivo properties and used a template−matching algorithm to assess stimulus separation. Such an AP latency−based scheme showed high reproducibility and sensitivity such that odor stimuli could be reliably separated independent of concentration. As in behavioral experiments we found that very dissimilar odors ("A vs. B") were accurately and rapidly discerned while very similar odors (binary mixtures, 0.4A/0.6B vs. 0.6A/0.4B) required up to 90 ms longer. As in lesion studies we find that AP latency−based representation is rather insensitive to disruption of large regions of the OB. The AP latency−based scheme described here, therefore, captures both temporal and psychophysical properties of olfactory processing and suggests that the onset patterns of M/TC activity in the OB represent stimulus specific features of olfactory stimuli

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Language(s): eng - English
 Dates: 2012-01-032012-04-092012-05-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Frontiers in Systems Neuroscience
  Abbreviation : Front Syst Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 6 Sequence Number: e30 Start / End Page: 1 - 8 Identifier: ISSN: 1662-5137
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5137