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  Alpha-1 adrenergic receptors gate rapid orientation-specific reduction in visual discrimination

Trevino, M., Frey, S., & Köhr, G. (2012). Alpha-1 adrenergic receptors gate rapid orientation-specific reduction in visual discrimination. Cerebral Cortex, 22(11), 2529-2541. doi:10.1093/cercor/bhr333.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1FA6-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1FA7-F
Genre: Journal Article
Alternative Title : Alpha-1 adrenergic receptors gate rapid orientation-specific reduction in visual discrimination

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http://dx.doi.org/10.1093/cercor/bhr333 (Any fulltext)
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 Creators:
Trevino, Mario1, Author              
Frey, Sebastian1, Author              
Köhr, Georg1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: experience−induced plasticity, mEPSC, mouse, NMDA receptors, visual cortex
 Abstract: Prolonged imbalance in sensory experience leads to dramatic readjustments in cortical representation. Neuromodulatory systems play a critical role in habilitating experience−induced plasticity and regulate memory processes in vivo. Here, we show that a brief period of intense patterned visual stimulation combined with systemic activation of alpha−1 adrenergic neuromodulator receptors (a1−ARs) leads to a rapid, reversible, and NMDAR−dependent depression of AMPAR−mediated transmission from ascending inputs to layer II/III pyramidal cells in the visual cortex of young and adult mice. The magnitude of this form of a1−AR long−term depression (LTD), measured ex vivo with miniature EPSC recordings, is graded by the number of orientations used during visual experience. Moreover, behavioral tests of visual function following the induction of a1−AR LTD reveal that discrimination accuracy of sinusoidal drifting gratings is selectively reduced at high spatial frequencies in a reversible, orientation−specific, and NMDARdependent manner. Thus, a1−ARs enable rapid cortical synaptic depression which correlates with an orientation−specific decrease in visual discrimination. These findings contribute to our understanding of how adrenergic receptors interact with neuronal networks in response to changes in active sensory experience to produce adaptive behavior

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Language(s): eng - English
 Dates: 2011-11-242012-11-01
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 22 (11) Sequence Number: - Start / End Page: 2529 - 2541 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440