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  Crystallography on a chip

Zarrine-Afsar, A., Barends, T., Müller, C., Fuchs, M. R., Lomb, L., Schlichting, I., et al. (2012). Crystallography on a chip. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen), 68(3), 321-323. doi:10.1107/S0907444911055296.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1FBB-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-1FBC-1
Genre: Journal Article
Alternative Title : Crystallography on a chip

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ActaCrystD_68_2012_321.pdf (Any fulltext), 508KB
 
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 Creators:
Zarrine-Afsar, Arash, Author
Barends, Thomas1, Author              
Müller, Christina, Author
Fuchs, Martin R., Author
Lomb, Lukas1, Author              
Schlichting, Ilme1, Author              
Miller, R.J. Dwayne, Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: crystal mounting; data collection
 Abstract: A new chip−based crystal−mounting approach for rapid room−temperature data collection from numerous crystals is described. This work was motivated by the recent development of X−ray free−electron lasers. These novel sources deliver very intense femtosecond X−ray pulses that promise to yield high−resolution diffraction data of nanocrystals before their destruction by radiation damage. Thus, the concept of ‘diffraction before destruction' requires rapid replenishment of the sample for each exposure. The chip promotes the self−assembly of an array of protein crystals on a surface. Rough features on the surface cause the crystals to adopt random orientations, allowing efficient sampling of reciprocal space

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Language(s): eng - English
 Dates: 2011-08-142011-12-222012-02-142012-03-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
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Title: Acta Crystallographica. Section D: Biological Crystallography (Copenhagen)
  Other : Acta Crystallogr D
Source Genre: Journal
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Publ. Info: [Copenhagen, Denmark : Published for the International Union of Crystallography by Munksgaard]
Pages: - Volume / Issue: 68 (3) Sequence Number: - Start / End Page: 321 - 323 Identifier: ISSN: 0907-4449
CoNE: https://pure.mpg.de/cone/journals/resource/954925562619