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  Response inhibition and its relation to multidimensional impulsivity

Wilbertz, T., Deserno, L., Horstmann, A., Neumann, J., Villringer, A., Heinze, H.-J., et al. (2014). Response inhibition and its relation to multidimensional impulsivity. NeuroImage, 103, 241-248. doi:10.1016/j.neuroimage.2014.09.021.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-264C-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1493-0
Genre: Journal Article

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 Creators:
Wilbertz, Tillmann1, Author
Deserno, Lorenz1, 2, Author              
Horstmann, Annette3, 4, 5, Author              
Neumann, Jane3, 4, 5, Author              
Villringer, Arno3, 4, 5, 6, 7, Author              
Heinze, Hans-Jochen8, 9, Author
Boehler, Carsten N.10, Author
Schlagenhauf, Florian1, 2, Author              
Affiliations:
1Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
8Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              
9Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
10Department of Experimental Psychology, Ghent University, Belgium, ou_persistent22              

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Free keywords: Stop signal task; Impulsivity; Urgency; IFG; Reward; fMRI
 Abstract: Impulsivity is a multidimensional construct that has been suggested as a vulnerability factor for several psychiatric disorders, especially addiction disorders. Poor response inhibition may constitute one facet of impulsivity. Trait impulsivity can be assessed by self-report questionnaires such as the widely used Barratt Impulsiveness Scale (BIS-11). However, regarding the multidimensionality of impulsivity different concepts have been proposed, in particular the UPPS self-report questionnaire ('Urgency', 'Lack of Premeditation', 'Lack of Perseverance', 'Sensation Seeking') that is based on a factor analytic approach. The question as to which aspects of trait impulsivity map on individual differences of the behavioral and neural correlates of response inhibition so far remains unclear. In the present study, we investigated 52 healthy individuals that scored either very high or low on the BIS-11 and underwent a reward-modulated Stop-signal task during fMRI. Neither behavioral nor neural differences were observed with respect to high- and low-BIS groups. In contrast, UPPS subdomain Urgency best explained inter-individual variability in SSRT scores and was further negatively correlated to right IFG/aI activation in 'Stop>Go' trials - a key region for response inhibition. Successful response inhibition in rewarded compared to nonrewarded stop trials yielded ventral striatal (VS) activation which might represent a feedback signal. Interestingly, only participants with low Urgency scores were able to use this VS feedback signal for better response inhibition. Our findings indicate that the relationship of impulsivity and response inhibition has to be treated carefully. We propose Urgency as an important subdomain that might be linked to response inhibition as well as to the use of reward-based neural signals. Based on the present results, further studies examining the influence of impulsivity on psychiatric disorders should take into account Urgency as an important modulator of behavioral adaptation.

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Language(s): eng - English
 Dates: 2014-09-092014-09-182014-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2014.09.021
PMID: 25241087
Other: Epub 2014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 103 Sequence Number: - Start / End Page: 241 - 248 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166