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  Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice

Abraham, N. M., Egger, V., Shimshek, D. R., Renden, R., Fukunaga, I., Sprengel, R., et al. (2010). Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice. Neuron, 65(3), 399-411. doi:10.1016/j.neuron.2010.01.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-208F-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-2090-0
Genre: Journal Article
Alternative Title : Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice

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 Creators:
Abraham, Nixon M.1, 2, Author              
Egger, Veronica2, Author              
Shimshek, Derya R.3, Author              
Renden, Robert2, Author              
Fukunaga, Izumi1, Author              
Sprengel, Rolf3, Author              
Seeburg, Peter H.3, Author              
Klugmann, Matthias, Author
Margrie, Troy W.1, 2, 3, Author              
Schaefer, Andreas T.1, 2, Author              
Kuner, Thomas2, 3, Author              
Affiliations:
1Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
3Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: SYSNEURO; MOLNEURO
 Abstract: Local inhibitory circuits are thought to shape neuronal information processing in the central nervous system, but it remains unclear how specific properties of inhibitory neuronal interactions translate into behavioral performance. In the olfactory bulb, inhibition of mitral/tufted cells via granule cells may contribute to odor discrimination behavior by refining neuronal representations of odors. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca2+ influx, increasing inhibition of mitral cells. On a behavioral level, discrimination of similar odor mixtures was accelerated while leaving learning and memory unaffected. In contrast, selective removal of NMDA receptors in granule cells slowed discrimination of similar odors. Our results demonstrate that inhibition of mitral cells controlled by granule cell glutamate receptors results in fast and accurate discrimination of similar odors. Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 65 (3) Sequence Number: - Start / End Page: 399 - 411 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565