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  Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.

Brusa, R., Zimmermann, F., Koh, D. S., Feldmeyer, D., Gass, P., Seeburg, P. H., et al. (1995). Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science, 270(5242), 1677-1680. doi:10.1126/science.270.5242.1677.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-21C6-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-21C7-C
Genre: Journal Article
Alternative Title : Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.

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 Creators:
Brusa, Rossella1, Author           
Zimmermann, Frank, Author
Koh, Duk Su2, Author           
Feldmeyer, Dirk2, Author           
Gass, Peter, Author
Seeburg, Peter H., Author           
Sprengel, Rolf1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to calcium. The codon for this arginine is introduced at the precursor messenger RNA (pre-mRNA) stage by site-selective adenosine editing of a glutamine codon. Heterozygous mice engineered by gene targeting to harbor an editing-incompetent GluR-B allele synthesized unedited GluR-B subunits and, in principal neurons and interneurons, expressed AMPA receptors with increased calcium permeability. These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function.

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Language(s): eng - English
 Dates: 1995-09-141995-10-241995-12-08
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: eDoc: 665421
DOI: 10.1126/science.270.5242.1677
URI: http://www.ncbi.nlm.nih.gov/pubmed/7502080
URI: https://www.sciencemag.org/content/270/5242/1677.full.pdf
Other: 6617
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 270 (5242) Sequence Number: - Start / End Page: 1677 - 1680 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1