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  Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences

Herb, A., Higuchi, M., Sprengel, R., & Seeburg, P. H. (1996). Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proceedings of the National Academy of Sciences of the United States of America, 93(5), 1875-1880. Retrieved from http://www.pnas.org/cgi/content/abstract/93/5/1875?maxtoshow%3D%26HITS%3D10%26hits%3D10%26RESULTFORMAT%3D%26searchid%3D1050127900416_1336%26stored_search%3D%26FIRSTINDEX%3D0%26minscore%3D5000%26journalcode%3Dpnas.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-2209-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-220A-E
Genre: Journal Article
Alternative Title : Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences

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PNAS_93_1996_1875.pdf (Any fulltext), 2MB
 
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 Creators:
Herb, Anne1, Author           
Higuchi, Miyoko1, Author           
Sprengel, Rolf1, Author           
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channel's Q/R site. We show by transcript analysis of minigenes transiently expressed in PC-12 cells that, in contrast to GluR-B pre-mRNA, where the two editing sites (Q/R and R/G) require base pairing with nearby intronic editing site complementary sequences (ECSs), editing in GluR5 and GluR6 pre-mRNAs recruits an ECS located as far as 1900 nucleotides distal to the Q/R site. The exon-intron duplex structure of the GluR5 and GluR6 pre-mRNAs appears to be a substrate of double-stranded RNA-specific adenosine deaminase. This enzyme when coexpressed in HEK 293 cells preferentially targets the adenosine of the Q/R site and of an unpaired position in the ECS which is highly edited in brain.

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Language(s): eng - English
 Dates: 1995-11-291996-03-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666451
URI: http://www.pnas.org/cgi/content/abstract/93/5/1875?maxtoshow%3D%26HITS%3D10%26hits%3D10%26RESULTFORMAT%3D%26searchid%3D1050127900416_1336%26stored_search%3D%26FIRSTINDEX%3D0%26minscore%3D5000%26journalcode%3Dpnas
URI: http://www.pnas.org/cgi/reprint/93/5/1875?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1050127900416_1336&stored_search=&FIRSTINDEX=0&minscore=5000&journalcode=pnas
Other: 4556
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 93 (5) Sequence Number: - Start / End Page: 1875 - 1880 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230