English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A mammalian RNA editing enzyme

Melcher, T., Maas, S., Herb, A., Sprengel, R., Seeburg, P. H., & Higuchi, M. (1996). A mammalian RNA editing enzyme. Nature, 379, 460-464. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8559253.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-2271-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-FFC1-0
Genre: Journal Article
Alternative Title : A candidate enzyme for RNA editing at the Q/R site in GluR-B pre-mRNA

Files

show Files
hide Files
:
Nature_379_1996_460.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Nature_379_1996_460.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
http://dx.doi.org/10.1038/379460a0 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Melcher, Thorsten1, Author              
Maas, Stefan1, Author              
Herb, Anne1, Author              
Sprengel, Rolf1, Author              
Seeburg, Peter H.1, Author              
Higuchi, Miyoko1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: EDITING of RNA1 by site-selective adenosine deamination alters codons in brain-expressed pre-messenger RNAs for glutamate receptor (GluR) subunits2–4 including a codon for a channel determinant (Q/R site) in GluR-B, which controls the Ca2+ permeability of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors5,6. Editing of GluR pre-mRNAs requires a double-stranded RNA (dsRNA) structure formed by exonic and intronic sequences4,7 and is catalysed by an unknown dsRNA adenosine deaminase. Here we report the cloning of complementary DNA for RED1, a dsRNA adenosine deaminase expressed in brain and peripheral tissues that efficiently edits the Q/R site in GluR-B pre-mRNA in vitro. This site is poorly edited by DRADA, which is distantly sequence-related to RED1. Both deaminases edit the R/G site in GluR-B pre-mRNA, indicating that members of an emerging gene family catalyse adenosine deamination in nuclear transcripts with distinct but overlapping substrate specificities.

Details

show
hide
Language(s): eng - English
 Dates: 1995-11-221995-12-191996-02-01
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 379 Sequence Number: - Start / End Page: 460 - 464 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238