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  Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Seim, I., Fang, X., Xiong, Z., Lobanov, A. V., Huang, Z., Ma, S., et al. (2013). Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii. Nature Communications, 4: 2212. doi:10.1038/ncomms3212.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-24F3-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-E483-7
Genre: Journal Article

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 Creators:
Seim, Inge, Author
Fang, Xiaodong, Author
Xiong, Zhiqiang, Author
Lobanov, Alexey V., Author
Huang, Zhiyong, Author
Ma, Siming, Author
Feng, Yue, Author
Turanov, Anton A., Author
Zhu, Yabing, Author
Lenz, Tobias L.1, Author              
Gerashchenko, Maxim V., Author
Fan, Dingding, Author
Yim, Sun Hee, Author
Yao, Xiaoming, Author
Jordan, Daniel, Author
Xiong, Yingqi, Author
Ma, Yong, Author
Lyapunov, Andrey N., Author
Chen, Guanxing, Author
Kulakova, Oksana I., Author
Sun, Yudong, AuthorLee, Sang-Goo, AuthorBronson, Roderick T., AuthorMoskalev, Alexey A., AuthorSunyaev, Shamil R., AuthorZhang, Guojie, AuthorKrogh, Anders, AuthorWang, Jun, AuthorGladyshev, Vadim N., Author more..
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

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Free keywords: Biological sciences; Evolution; Genetics;
 Abstract: ats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.

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Language(s): eng - English
 Dates: 2012-12-202013-06-262013-08-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ncomms3212
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 8 S. Volume / Issue: 4 Sequence Number: 2212 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723