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  Real-time phase-contrast flow MRI of haemodynamic changes in the ascending aorta and superior vena cava during Mueller manoeuvre.

Fasshauer, M., Joseph, A., Kowallick, J. T., Unterberg-Buchwald, C., Merboldt, K. D., Voit, D., et al. (2014). Real-time phase-contrast flow MRI of haemodynamic changes in the ascending aorta and superior vena cava during Mueller manoeuvre. Clinical Radiology, 69(10), 1066-1071. doi:10.1016/j.crad.2014.06.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-262B-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-BC25-2
Genre: Journal Article

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 Creators:
Fasshauer, M., Author
Joseph, A.1, Author              
Kowallick, J. T., Author
Unterberg-Buchwald, C., Author
Merboldt, K. D., Author
Voit, D.1, Author              
Steinmetz, M., Author
Staab, W., Author
Schätz, S.1, Author              
Zhang, S.1, Author              
Frahm, J.1, Author              
Lotz, J., Author
Sohns, J. M., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: AIM: To evaluate the potential of real-time phase-contrast flow magnetic resonance imaging (MRI) at 40 ms resolution for the simultaneous determination of blood flow in the ascending aorta (AA) and superior vena cava (SVC) in response to reduced intrathoracic pressure (Mueller manoeuvre). MATERIALS AND METHODS: Through-plane flow was assessed in 20 healthy young subjects using real-time phase-contrast MRI based on highly undersampled radial fast low-angle shot (FLASH) with image reconstruction by regularized non-linear inversion. Haemodynamic alterations (three repetitions per subject = 60 events) were evaluated during normal breathing (10 s), inhalation with nearly closed epiglottis (10 s), and recovery (20 s). RESULTS: Relative to normal breathing and despite interindividual differences, reduced intrathoracic pressure by at least 30 mmHg significantly decreased the initial peak mean velocity (averaged across the lumen) in the AA by -24 +/- 9% and increased the velocity in the SVC by +28 +/- 25% (p < 0.0001, n = 23 successful events). Respective changes in flow volume per heartbeat were -25 +/- 9% in the AA and +49 +/- 44% in the SVC (p < 0.0001, n = 23). Flow parameters returned to baseline during sustained pressure reduction, while the heart rate was elevated by 10% (p < 0.0001) after the start (n = 24) and end (n = 17) of the manoeuvre. CONCLUSIONS: Real-time flow MRI during low intrathoracic pressure non-invasively revealed quantitative haemodynamic adjustments in both the AA and SVC. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2014-07-222014-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.crad.2014.06.004
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Title: Clinical Radiology
Source Genre: Journal
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Pages: - Volume / Issue: 69 (10) Sequence Number: - Start / End Page: 1066 - 1071 Identifier: -