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  miRNA-based buffering of the cobblestone–lissencephaly-associated extracellular matrix receptor ​dystroglycan via its alternative 3′-UTR.

Yatsenko, A. S., Marrone, A. K., & Shcherbata, H. R. (2014). miRNA-based buffering of the cobblestone–lissencephaly-associated extracellular matrix receptor ​dystroglycan via its alternative 3′-UTR. Nature Communications, 5: 4906. doi:10.1038/ncomms5906.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-2657-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6EC8-3
Genre: Journal Article

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 Creators:
Yatsenko, A. S.1, Author              
Marrone, A. K.1, Author              
Shcherbata, H. R.1, Author              
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

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 Abstract: Many proteins are expressed dynamically during different stages of cellular life and the accuracy of protein amounts is critical for cell endurance. Therefore, cells should have a perceptive system that notifies about fluctuations in the amounts of certain components and an executive system that efficiently restores their precise levels. At least one mechanism that evolution has employed for this task is regulation of 3′-UTR length for microRNA targeting. Here we show that in Drosophila the microRNA complex miR-310s acts as an executive mechanism to buffer levels of the muscular dystrophy-associated extracellular matrix receptor ​dystroglycan via its alternative 3′-UTR. miR-310s gene expression fluctuates depending on ​dystroglycan amounts and ​nitric oxide signalling, which perceives ​dystroglycan levels and regulates microRNA gene expression. Aberrant levels of ​dystroglycan or deficiencies in miR-310s and ​nitric oxide signalling result in cobblestone brain appearance, resembling human lissencephaly type II phenotype.

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Language(s): eng - English
 Dates: 2014-09-18
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/ncomms5906
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Title: Nature Communications
Source Genre: Journal
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Pages: 17 Volume / Issue: 5 Sequence Number: 4906 Start / End Page: - Identifier: -