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  Regional reproducibility of calibrated BOLD functional MRI: Implications for the study of cognition and plasticity

Krieger, S., Gauthier, C., Ivanov, D., Huber, L., Roggenhofer, E., Sehm, B., et al. (2014). Regional reproducibility of calibrated BOLD functional MRI: Implications for the study of cognition and plasticity. NeuroImage, 101, 8-20. doi:10.1016/j.neuroimage.2014.06.072.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-2C1A-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F0C-3
Genre: Journal Article

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 Creators:
Krieger, Steffen1, 2, Author              
Gauthier, Claudine3, Author              
Ivanov, Dimo3, 4, Author              
Huber, Laurentius1, Author              
Roggenhofer, Elisabeth5, 6, 7, Author              
Sehm, Bernhard6, Author              
Turner, Robert3, Author              
Egan, Gary F.2, Author
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Monash Biomedical Imaging, Monash University, Melbourne, Australia, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
4Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              

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 Abstract: Calibrated BOLD fMRI is a promising alternative to the classic BOLD contrast due to its reduced venous sensitivity and greater physiological specificity. The delayed adoption of this technique for cognitive studies may stem partly from a lack of information on the reproducibility of these measures in the context of cognitive tasks. In this study we have explored the applicability and reproducibility of a state-of-the-art calibrated BOLD technique using a complex functional task at 7 tesla. Reproducibility measures of BOLD, CBF, CMRO2 flow-metabolism coupling n and the calibration parameter M were compared and interpreted for three ROIs. We found an averaged intra-subject variation of CMRO2 of 8% across runs and 33% across days. BOLD (46% across runs, 36% across days), CBF (33% across runs, 46% across days) and M (41% across days) showed significantly higher intra-subject variability. Inter-subject variability was found to be high for all quantities, though CMRO2 was the most consistent across brain regions. The results of this study provide evidence that calibrated BOLD may be a viable alternative for longitudinal and cognitive MRI studies.

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Language(s): eng - English
 Dates: 2013-12-272014-06-282014-07-052014-11-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2014.06.072
PMID: 24629352
Other: Epub 2014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 101 Sequence Number: - Start / End Page: 8 - 20 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166