English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Simultaneous acquisition of cerebral blood volume-, blood flow-, and blood oxygenation-weighted MRI signals at ultra-high magnetic field

Krieger, S., Huber, L., Poser, B. A., Turner, R., & Egan, G. F. (2015). Simultaneous acquisition of cerebral blood volume-, blood flow-, and blood oxygenation-weighted MRI signals at ultra-high magnetic field. Magnetic Resonance in Medicine, 74(2), 513-517. doi:10.1002/mrm.25431.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-2C1C-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7931-E
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Krieger, Steffen1, 2, Author              
Huber, Laurentius1, Author              
Poser, Benedikt A.3, Author
Turner, Robert4, Author              
Egan, Gary F.2, Author
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Monash Biomedical Imaging, Monash University, Melbourne, Australia, ou_persistent22              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

Content

show
hide
Free keywords: Cerebral blood volume; Cerebral blood flow; BOLD; Ultra-high field; Vascular space occupancy; VASO; Functional MRI
 Abstract: Purpose Yang et al. proposed an MRI technique for the simultaneous acquisition of cerebral blood volume (CBV), cerebral blood flow (CBF), and blood oxygenation level-dependent (BOLD)-weighted MRI signals (9). The purpose of this study was to develop modified version of the Yang sequence, which utilizes the advantages of 7 Tesla, leading to a robust and reliable MRI sequence. Methods The inversion recovery-based MR pulse sequence introduced here involves slice-saturation slab-inversion vascular space occupancy (SI-SS-VASO) MRI, double echo planar imaging readouts for arterial spin labeling, and VASO in order to correct for BOLD contamination, and a separate BOLD acquisition to minimize inversion effects on the BOLD signal. A standard visual stimulus block design was used to evaluate the spatial and temporal characteristics of CBV-, CBF-, and BOLD-weighted images. Results The high signal-to-noise ratio and spatial resolution of this method leads to robust activation maps. This technique enables the investigation of the differential spatial specificity and temporal characteristics of the different modalities. Conclusion The pulse sequence could be a powerful tool for studies of neurovascular coupling, hemodynamic response, or calibrated BOLD.

Details

show
hide
Language(s): eng - English
 Dates: 2014-03-052014-08-072014-09-052015-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.25431
PMID: 25195774
Other: Epub 2014
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 74 (2) Sequence Number: - Start / End Page: 513 - 517 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149