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  Cortical lamina-dependent blood volume changes in human brain at 7 T

Huber, L., Goense, J., Kennerley, A. J., Trampel, R., Guidi, M., Ivanov, D., et al. (2015). Cortical lamina-dependent blood volume changes in human brain at 7 T. NeuroImage, 107, 23-33. doi:10.1016/j.neuroimage.2014.11.046.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-33DB-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7915-E
Genre: Journal Article

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 Creators:
Huber, Laurentius1, Author              
Goense, Jozien2, 3, Author
Kennerley, Aneurin J.4, Author
Trampel, Robert5, Author              
Guidi, Maria1, Author              
Ivanov, Dimo6, Author
Neef, Nicole7, Author              
Gauthier, Claudine5, Author              
Turner, Robert5, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              
3Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
4Centre for Signal Processing in Neuroimaging and Systems Neuroscience, University of Sheffield, United Kingdom, ou_persistent22              
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634550              
6Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
7Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Vascular space occupancy; SS-SI-VASO; Cerebral blood volume; Cortical profiles; Layer-dependent fMRI; Negative BOLD response; 7 Tesla MRI
 Abstract: Cortical layer-dependent high (sub-millimeter) resolution functional magnetic resonance imaging (fMRI) in human or animal brain can be used to address questions regarding the functioning of cortical circuits, such as the effect of different afferent and efferent connectivities on activity in specific cortical layers. The sensitivity of gradient echo (GE) blood oxygenation level-dependent (BOLD) responses to large draining veins reduces its local specificity and can render the interpretation of the underlying laminar neural activity impossible. The application of the more spatially specific cerebral blood volume (CBV)-based fMRI in humans has been hindered by the low sensitivity of the noninvasive modalities available. Here, a vascular space occupancy (VASO) variant, adapted for use at high field, is further optimized to capture layer-dependent activity changes in human motor cortex at sub-millimeter resolution. Acquired activation maps and cortical profiles show that the VASO signal peaks in gray matter at 0.8–1.6 mm depth, and deeper compared to the superficial and vein-dominated GE-BOLD responses. Validation of the VASO signal change versus well-established iron-oxide contrast agent based fMRI methods in animals showed the same cortical profiles of CBV change, after normalization for lamina-dependent baseline CBV. In order to evaluate its potential of revealing small lamina-dependent signal differences due to modulations of the input-output characteristics, layer-dependent VASO responses were investigated in the ipsilateral hemisphere during unilateral finger tapping. Positive activation in ipsilateral primary motor cortex and negative activation in ipsilateral primary sensory cortex were observed. This feature is only visible in high-resolution fMRI where opposing sides of a sulcus can be investigated independently because of a lack of partial volume effects. Based on the results presented here, we conclude that VASO offers good reproducibility, high sensitivity and lower sensitivity than GE-BOLD to changes in larger vessels, making it a valuable tool for layer-dependent fMRI studies in humans.

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Language(s): eng - English
 Dates: 2014-11-102014-12-032015-02-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2014.11.046
PMID: 25479018
Other: Epub 2014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 107 Sequence Number: - Start / End Page: 23 - 33 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166