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  Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization

Wortmann, L., Ilyas, S., Niznansky, D., Valldor, M., Arroub, K., Berger, N., et al. (2014). Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization. ACS Applied Materials & Interfaces, 6(19), 16631-16642. doi:10.1021/am503068r.

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 Creators:
Wortmann, Laura1, Author
Ilyas, Shaista1, Author
Niznansky, Daniel1, Author
Valldor, Martin2, Author              
Arroub, Karim1, Author
Berger, Nadja1, Author
Rahme, Kamil1, Author
Holmes, Justin1, Author
Mathur, Sanjay1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Martin Valldor, Physics of Correlated Matter, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863454              

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 Abstract: A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.

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Language(s): eng - English
 Dates: 2014-09-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000343018200021
DOI: 10.1021/am503068r
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Title: ACS Applied Materials & Interfaces
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 6 (19) Sequence Number: - Start / End Page: 16631 - 16642 Identifier: ISSN: 1944-8244
CoNE: https://pure.mpg.de/cone/journals/resource/1944-8244