ausblenden:
Schlagwörter:
aldehydes; aldol reaction; asymmetric catalysis; organocatalysis; proline
Zusammenfassung:
The proline-catalyzed asymmetric aldol reaction between aliphatic aldehydes and acetone has, to date, remained underdeveloped. Challenges in controlling this reaction include avoiding undesired side reactions such as aldol condensation and self-aldolization. In recent years we have developed optimized conditions, which enable high yields and good to excellent enantioselectivities, and which are presented in this communication.
