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  The Catalytic Asymmetric Abramov Reaction

Guin, J., Wang, Q., van Gemmeren, M., & List, B. (2015). The Catalytic Asymmetric Abramov Reaction. Angewandte Chemie International Edition, 54(1), 355-358. doi:10.1002/anie.201409411.

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 Creators:
Guin, Joyram1, Author              
Wang, Qinggang1, Author              
van Gemmeren, Manuel1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              

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Free keywords: Abramov reaction; disulfonimides; hydrophosphonylations; organocatalysis; α-hydroxy phosphonates
 Abstract: The first catalytic enantioselective Abramov reaction is described. The process is based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids the difficulties encountered with metal-based catalysts. Several functionalized α-hydroxy phosphonates were synthesized in good yields and with excellent enantiomeric ratios of up to >99:1. The process was shown to be scalable and up to 1 g of starting material could be employed under mild reaction conditions.

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Language(s): eng - English
 Dates: 2014-11-132015-01-02
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201409411
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 54 (1) Sequence Number: - Start / End Page: 355 - 358 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851