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  Studies on DNA Cleavage by Cytotoxic Pyrrole Alkaloids Reveal the Distinctly Different Behavior of Roseophilin and Prodigiosin Derivatives

Fürstner, A., & Grabowski, E. J. (2001). Studies on DNA Cleavage by Cytotoxic Pyrrole Alkaloids Reveal the Distinctly Different Behavior of Roseophilin and Prodigiosin Derivatives. ChemBioChem: A European Journal of Chemical Biology, 2(9), 706-709. doi:10.1002/1439-7633(20010903)2:9<706:AID-CBIC706>3.0.CO;2-J.

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 Creators:
Fürstner, Alois1, Author              
Grabowski, Eric Jarek1, Author              
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: alkaloids; antitumor agents; DNA cleavage; prodigiosins; pyrroles
 Abstract: Similar structure, same effect, different mechanism: The alkaloids nonylprodigiosin (1) and roseophilin (2) share several structural motifs and are both highly cytotoxic. While the former induces effective strand cleavage of supercoiled DNA in the presence of CuII, the latter is totally inactive. A structure–activity profile for this class of pyrrole alkaloids has been established by testing various analogues of these lead compounds.

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Language(s): eng - English
 Dates: 2001-03-192001-09-102001-09-03
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: ChemBioChem : A European Journal of Chemical Biology
  Other : ChemBioChem
Source Genre: Journal
 Creator(s):
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: 4 Volume / Issue: 2 (9) Sequence Number: - Start / End Page: 706 - 709 Identifier: ISSN: 1439-4227
CoNE: https://pure.mpg.de/cone/journals/resource/110978984568897_1